Production of Erythromycin E by Pathogenic Nocardia brasiliensis.
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منابع مشابه
Production of erythromycin E by pathogenic Nocardia brasiliensis.
Since the discovery of erythromycin A (1; Fig. 1)1} more than 25 biosynthetic representatives of this family of 14-membered macrolide antibiotics have been reported. Most of erythromycins are produced by the genera Saccharopolyspora and Streptomyces but few by Nocardia strains2). Erythromycin E (2; Fig. 1) is distinguishable from all the other known macrolide antibiotics and other microbial met...
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Rifampin was glycosylated by a pathogenic species of Nocardia, i.e., Nocardia brasiliensis. The structures of two glycosylated compounds (RIP-1 and RIP-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(O-[beta-D-glucopyranosyl])rifamycin SV and 23-(O-[beta-D-glucopyranosyl])rifampin, respectively. Both compounds lacked antimicrobial activity against other gr...
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A survey of five Nocardia spp. with respect to susceptibility towards three macrolides (erythromycin, rokitamycin, and midecamycin) showed that the Nocardia spp. have different susceptibility profiles. Most of the resistance was due to the inactivation of the macrolides by phosphorylation, glycosylation, reduction, deacylation, or a combination thereof.
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The reported case is of primary pulmonary nocardiosis, caused by Nocardia brasiliensis, in a immunocompromised patient, which ended fatally despite appropriate treatment. The partially acid fast filamentous bacterium was predominant on direct examination of the sputum. It was cultured on blood agar, MacConkey agar and by paraffin baiting technique. The bacterium was resistant to cotrimoxazole, ...
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1. Polasky, N., Polasky, S., Magenheim, H. & Abrams, N.R. Giant cell arteritis. Review and report of a case. JAMA 1965, 191: 341-343. 2. Nehra, P.C., Ramus, D.M. & Peterson, J. Giant-cell arteritis of the uterus with associated temporal arteritis: a case report. Obstet Gynecol 1990, 76: 935-938. 3. Padwell, A. Isolated arteritis of the uterine cervix. Three cases report. Br J Obstet Gynaecol 19...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1999
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.52.201